The Role of Intestinal Flora and Its Metabolites in The Development of Atherosclerosis

VernacularTitle:肠道菌群及其代谢产物在动脉粥样硬化发生发展中的作用
Author: Aiyun WANG ¹ ; Yuting WANG ; Jing CAI ; Ruoyan NI ; Caiying LUO ; Zhuo YU ; Peng CHEN
Author Information

1. 昆明医科大学药学院暨云南省天然药物药理重点实验室;昆明医科大学现代生物医药产业学院,云南昆明 650500
Keywords: Intestinal flora; Metabolites; Atherosclerosis; Treatment
From: Journal of Kunming Medical University 2024;45(12):160-166
CountryChina
Language:Chinese
Abstract: Intestinal flora and their metabolites play an important role in the occurrence and development of cardiovascular diseases such as atherosclerosis(AS),and have become an important target for the prevention and treatment of AS.In this paper,we focus on the intestinal microecological environment and focus on the relationship between intestinal flora metabolites such as trimethylamine oxide(TMAO),short-chain fatty acids(SCFA),phenylacetylglutamine(PAG),lipopolysaccharides(LPS),and bile acids(BA),and AS.At the same time,we also discuss the therapeutic strategies of AS that start from adjusting the intestinal flora and its metabolites,with the hope of opening up a new avenue of AS prevention and treatment.We hope to open up new avenues for the prevention and treatment of AS.