Correlation between Serum Levels of Anti-HBC,CHE,and Apolipoprotein AI and the Development of Viral Hepatitis
10.12259/j.issn.2095-610X.S20241221
- VernacularTitle:血清抗-HBC、CHE、载脂蛋白AI的水平与病毒性肝炎发展的相关性
- Author:
Su XU
1
;
Yuqing LIU
;
Xingwang ZHENG
Author Information
1. 南京市浦口区中医院检验科,江苏南京 211800
- Keywords:
Viral hepatitis;
Hepatitis B core anbody;
Cholinesterase;
Apolipoprotein
- From:
Journal of Kunming Medical University
2024;45(12):147-152
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum hepatitis B core anbody(anti-HBC),cholinesterase(CHE)and apolipoprotein AI(ApoAI)and the development of viral hepatitis.Methods 388 patients with viral hepatitis admitted to Nanjing Pukou District Hospital of Traditional Chinese Medicine from January 2021 to January 2024 were selected as the observation group,another 68 cases of health check-ups in medical check-up centre of Nanjing Pukou District Hospital of Traditional Chinese Medicine during the same period were selected as the control group.The serum levels of anti-HBC,CHE,and apolipoprotein AI between the observation group and the control group were compared.To compare the serum anti-HBC,CHE,ApoAI levels in patients with different disease severity of chronic hepatitis in the observation group.To compare the number of positive cases of serum anti-HBC,CHE,ApoAI in patients with different disease types in the observation group.To compare the serum anti-HBC,CHE,ApoAI levels in patients with different grades of cirrhosis in the observation group.Results Serum anti-HBC levels(4.52±0.63)log10PEIU/mL were higher in the observation group than in the control group(1.12±0.26)log10PEIU/mL,and the differences were statistically significant(t=-43.822,P＜0.001),while CHE(4.09±0.91)kU/L,ApoAI(102.54±5.95)mg/dL were lower than the control group(10.65±1.73)kU/L,(120.17±6.06)mg/dL,and the differences were statistically significant(t=46.580,22.477,P＜0.001);differences in serum anti-HBC,CHE,and ApoAI levels among patients with different severity of chronic hepatitis in the observation group were statistically significant(P＜0.05),and the serum levels of anti-HBC levels showed mild chronic hepatitis＜moderate chronic hepatitis＜severe chronic hepatitis,while the levels of CHE and ApoAI showed mild chronic hepatitis＞moderate chronic hepatitis＞severe chronic hepatitis the difference was statistically significant(P＜0.05);the number of positive cases of serum anti-HBC,CHE,ApoAI in acute jaundiced hepatitis,severe chronic hepatitis,cirrhosis and hepatocellular carcinoma were significantly higher than those of chronic hepatitis in mild and moderate forms and the difference was statistically significant(P＜0.05).The differences in serum anti-HBC,CHE,and ApoAI levels in patients with different grades of cirrhosis in the observation group were statistically significant(P＜0.05)and serum levels of anti-HBC levels increased continuously with the progression of the disease,whereas CHE and ApoAI decreased continuously with the difference being statistically significant(P＜0.05).Conclusion The levels of serum anti-HBC in patients with viral hepatitis are significantly increased,while the levels of CHE and apolipoprotein AI are significantly decreased,and the levels of serum anti-HBC,CHE and apolipoprotein AI are related to the development of the disease,which contributes to the development of the disease.
