The Predictive Value of sFlt-1,SDC4,and sST2 on the Therapeutic Effect of Children with Purpuric Nephritis
10.12259/j.issn.2095-610X.S20241219
- VernacularTitle:sFlt-1、SDC4、sST2对紫癜性肾炎患儿疗效的预测价值
- Author:
Xiaoling YANG
1
;
Zhen LIU
;
Yu WANG
;
Jing WANG
Author Information
1. 信阳一五四医院儿科,河南信阳 464000
- Keywords:
Purpuric nephritis;
Soluble vascular endothelial growth factor receptor-1;
Multiligand proteoglycan-4;
Soluble human matrix metalloproteinase-2;
Prediction
- From:
Journal of Kunming Medical University
2024;45(12):135-140
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the levels of soluble vascular endothelial growth factor receptor-1(sFlt-1),polyligand proteoglycan-4(SDC4),soluble human stromal lysin 2(sST2)in serum and renal histopathological grading in children with Henoch-Schnlein purpura nephritis(HSPN),and analyze their predictive value for therapeutic efficacy.Methods A retrospective study was conducted,in which 98 children with HSPN admitted to Xinyang 154th Hospital from April 2021 to April 2023 were selected as the research subjects.According to the clinical efficacy after 2 months of treatment,they were divided into an effective group of 78 cases and an ineffective group of 20 cases.Their clinical data and the levels of serum sFlt-1,SDC4,and sST2 before and after treatment were compared.Multivariate logistic regression analysis was used to analyze the factors affecting the efficacy.The predictive value of serum sFlt-1,SDC4,and sST2 levels after 1 month of treatment on the efficacy after 2 months of treatment was analyzed.Results As the pathological grade increased,the levels of serum sFlt-1,SDC4,and sST2 showed an upward trend(P＜0.05);the levels of serum sFlt-1,SDC4,and sST2 in the ineffective group after 1 month of treatment were higher than those in the effective group(P＜0.05);the symptom score of purpura,immunoglobulin A(IgA)level,and the levels of serum sFlt-1,SDC4,and sST2 after 1 month of treatment were independent risk factors for efficacy(P＜0.05);the AUC of serum sFlt-1,SDC4,and sST2 levels combined to predict efficacy after 1 month of treatment was greater than that of any two combined predictions or single indicator predictions(P＜0.05).Conclusion The levels of serum sFlt-1,SDC4,and sST2 in children with HSPN are closely related to the pathological grading of the kidney tissue.The combined detection of their levels has certain predictive value for the therapeutic effect.
