Clinical Significance of Multidrug Resistance-1 Gene Over-expression in Childhood Acute Lymphoblastic Leukemia.
- Author:
Seung Hwan OH
1
Author Information
1. Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. osh@yumc.yonsei.ac.kr
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Acute lymphoblastic leukemia;
P-glycoprotein;
MDR-1;
Flow cytometry
- MeSH:
Bone Marrow;
Disease-Free Survival;
Drug Resistance, Multiple;
Flow Cytometry;
Humans;
Leukocyte Count;
P-Glycoprotein;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*;
Recurrence;
Remission Induction;
Survival Rate
- From:Korean Journal of Pediatric Hematology-Oncology
2001;8(2):206-214
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The object of this study is to elucidate the clinical significance of multidrug resistance gene-1 (MDR-1) over-expression in childhood acute lymphoblastic leukemia. METHODS: 41 bone marrow specimen from 36 patients of childhood acute lymphoblastic leukemia (ALL) were stained with anti-P-glycoprotein antibody and analyzed with flow cytometry. The presence of P-glycoprotein was compared with the clinical parameters of patients. RESULTS: P-glycoprotein was present in 17 cases (41.5%). There was a tendency that the expression of P-glycoprotein showed positive relationship with relapse rate and negative relationship with event free survival time. There was no statistically significant correlation between the over-expression of P-glycoprotein and clinical parameters such as complete remission induction, two years survival rate, age, sex, initial leukocyte counts, and immunophenotype. CONCLUSION: At this study, the over-expression of MDR-1 did not show any statistically significant clinical impact on childhood ALL. Because sample numbers of this study were not enough to find the significance of MDR-1 over-expression on clinical course of childhood ALL such as relapse and event free survival rate, there should be prospective, multi-center, well-controlled study to elucidate the impact of MDR-1 over-expression in childhood ALL.
