Association between sublingual microcirculation, high mobility group box 1 protein, and sepsis-induced coagulopathy: a clinical correlation study
10.3760/cma.j.issn.1671-0282.2025.06.015
- VernacularTitle:舌下微循环、高迁移率族蛋白B1与脓毒症性凝血病的相关性研究
- Author:
Yu LIANG
1
;
Rui DONG
;
Li MA
;
Shuangfeng LI
;
Ruixia ZHANG
;
Shuya HUANG
;
Yubao LI
;
Yanqiu GAO
Author Information
1. 郑州大学，郑州 450066
- Keywords:
Sepsis;
Sepsis-induced coagulopathy;
Disseminated intravascular coagulation;
High mobility group box 1;
Sublingual microcirculation;
Proportion of perfused
- From:
Chinese Journal of Emergency Medicine
2025;34(6):837-843
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between sublingual microcirculatory perfusion vessel proportion (PPV), high mobility group protein B1 (HMGB1), and sepsis-induced coagulopathy (SIC), and to identify early predictive markers for clinical intervention.Methods:A total of 66 septic patients admitted to the Respiratory Intensive Care Unit (RICU) between November 2021 and May 2024 were enrolled. Based on SIC diagnosis within 24 hours of admission, patients were categorized into SIC ( n=36) and non-SIC ( n=30) groups. Clinical parameters, including prothrombin time (PT), activated partial thromboplastin time (APTT), sublingual PPV, and serum HMGB1 levels (measured at 0 h and 6 h), were analyzed. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to identify independent predictors. Results:Compared with the non-SIC group, the SIC group demonstrated significantly prolonged PT ( P<0.05) and APTT ( P<0.05), elevated 0 h lactate levels, and increased 6 h HMGB1. Spearman analysis revealed a positive correlation between 6 h PPV and platelet count ( P<0.05), while an inverse correlation was observed with 6 h PT ( P<0.05). Multivariate regression identified APTT, 6 h PPV, and 6 h HMGB1 as independent predictors of SIC. ROC analysis yielded AUC values of 0.732 for APTT, 0.802 for 6 h PPV, and 0.765 for 6 h HMGB1. The combination of 6 h PPV and HMGB1 further improved predictive accuracy (AUC=0.873). Conclusions:Prolonged APTT, decreased 6 h PPV, and elevated 6h HMGB1 are key indicators of SIC. Integrated assessment of these markers enhances early risk stratification in septic patients, facilitating timely clinical intervention.
