Association between serum calcium and 30-day mortality risk in patients with community-acquired pneumonia
10.3760/cma.j.issn.1671-0282.2025.04.010
- VernacularTitle:血清钙与社区获得性肺炎患者30 d死亡风险相关性研究
- Author:
Li HUANG
1
;
Zhengbin WANG
;
Yan ZHANG
;
Shuo WANG
;
Xiao YUE
;
Yanxia GAO
Author Information
1. 郑州大学第一附属医院急诊医学部，郑州 450052
- Keywords:
Serum calcium;
Albumin-corrected serum calcium;
Community-acquired bacterial pneumonia;
30-day mortality risk
- From:
Chinese Journal of Emergency Medicine
2025;34(4):533-539
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between albumin-corrected serum calcium (ACSC) levels and 30-day all-cause mortality in patients hospitalized for community-acquired bacterial pneumonia (CABP).Methods:A secondary analysis was conducted on 1 899 patients with CABP from a Norwegian cohort study. The relationship between baseline ACSC levels and 30-day mortality was assessed using multivariable logistic regression models, adjusted for potential confounders.Results:A significant positive correlation was found between ACSC levels and 30-day mortality risk after adjusting for confounding variables ( OR=1.95, 95% CI=1.48-2.58). When ACSC levels were categorized into tertiles (T1-T3), a trend analysis revealed that the T2 and T3 groups had significantly higher mortality risks compared to the lowest tertile (T1), with odds ratios ( OR) and 95% confidence intervals ( CI) of 1.52(95% CI: 0.97-2.38) and 2.21 (95% CI: 1.44-3.39), respectively ( P for trend <0.001). Subgroup analyses demonstrated no significant interactions across predefined subgroups (all P for interaction > 0.05). Conclusions:In patients with CABP and admission ACSC levels of ≥8.6 mg/dL, higher ACSC levels were positively associated with an increased risk of 30-day mortality. These findings highlight the potential prognostic value of ACSC levels in CABP patients.
