Research progress on osteoporosis induced by cold exposure
10.7644/j.issn.1674-9960.2025.10.010
- VernacularTitle:冷暴露致骨质疏松症的研究进展
- Author:
Lu JIN
1
;
Xi LI
;
Yongqiang ZHANG
;
Jun LI
;
Danfeng YANG
Author Information
1. 军事科学院军事医学研究院,天津 300050
- Keywords:
cold environment;
osteoporosis;
bone density
- From:
Military Medical Sciences
2025;49(10):785-790
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis is a globally prevalent metabolic bone disease,with bone homeostasis imbalance being its key pathogenic mechanism.Over the years,studies on the relationship between ambient temperature and bone health have shown heterogeneous results due to different conditions.Epidemiological studies indicate that the incidence of osteoporotic fractures varies geographically and climatically.People in cold regions experience earlier bone loss,and high-latitude cold areas are high-risk zones for hip fractures.Osteoporosis is more prevalent in North China that in South China.Additionally,the early stage of the disease is insidious,highlighting the need for early prevention and treatment across the entire population.Mechanistically,low temperatures affect acral bone development,reduce bone blood circulation,cause degradation of bone microstructure,and increase osteocyte apoptosis,thereby promoting bone resorption and reducing bone mass.This review aims to provide data and new lines of thought for the early precise prevention and effective clinical treatment of osteoporosis in cold regions.
