Effects of total flavonoid extracted from Xiaobuxin-Tang on local field potentials of the frontal cortexin mice
10.7644/j.issn.1674-9960.2025.10.004
- VernacularTitle:小补心汤总黄酮对小鼠前额叶皮质局部场电位的作用
- Author:
Jin YANG
1
;
Jincao LI
;
Shuzhuo ZHANG
;
Yankai WANG
;
Renhong QIU
;
Yongfang GU
;
Rui XUE
;
Shuo LI
;
Yang ZHANG
;
Qiongyin FAN
;
Youzhi ZHANG
;
Shuang LIU
Author Information
1. 佳木斯大学基础医学院,黑龙江佳木斯 154007;军事科学院军事医学研究院,北京 100850
- Keywords:
XBXT-2;
local field potential;
θ oscillations;
γ oscillations;
cortical electrodes
- From:
Military Medical Sciences
2025;49(10):747-753
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pharmacological mechanism through which total flavonoids extracted from Xiaobuxin-Tang(XBXT-2)affects neural network activities in the frontal cortex by focusing on the effects of XBXT-2 on the cortical field potentials in the frontal association cortex(FrA)in mice.Methods Cortical electrodes were implanted into the skull of C57BL/6J mice targeting the FrA.After a 7-day recovery period,the mice were administered XBXT-2 intragastrically at a dose of 100 mg/kg,and 1 hour later,local field potential(LFP)in the FrA were recorded for 30 minutes.Spectral analysis of the data was performed using Neuro Explorer software.Changes in the power spectral density of α,β,θ,γ,and δ frequency bands before and after drug administration were analyzed using GraphPad Prism 10.3.Phase-amplitude coupling of θ and γ oscillations was analyzed using Matlab 2021 software.Results It was found that the oral administration of XBXT-2 significantly suppressed high-frequency γ oscillations while simultaneously enhancing θ,β,α,and δ oscillations in FrA of mice compared to the control.Furthermore,XBXT-2 treatment markedly strengthened the phase-amplitude coupling between θ and γ oscillations.Conclusion XBXT-2 possibly affects emotional and cognitive functions by modulating neural network activity in FrA and enhancing θ-γ phase-amplitude coupling in mice.
