Research progress in gene therapy for heart failure
10.7644/j.issn.1674-9960.2025.09.010
- VernacularTitle:心力衰竭基因治疗的研究进展
- Author:
Yan CONG
1
;
Ran ZHENG
;
Ming LI
;
Zhi XIU
;
Quan WAN
Author Information
1. 内蒙古民族大学临床医学院,内蒙古通辽 028000
- Keywords:
heart failure;
gene therapy;
gene targets;
targeted therapy;
gene delivery
- From:
Military Medical Sciences
2025;49(9):707-711
- CountryChina
- Language:Chinese
-
Abstract:
Heart failure(HF)is a cardiovascular disease with a high prevalence and mortality rate worldwide,and despite the widespread use of existing drugs,device intervetions and surgical procedures,the clinical outcomes are still unsatisfactory.The exploration of new methods to treat HF is still an urgent problem.Gene therapy provides a new therapeutic strategy for HF by targeting the regulation of pathogenic genes.This article systematically reviewed the delivery system optimization,key targets and clinical translational challenges of gene therapy for HF,aiming to provide a theoretical basis for the optimization of treatment strategies.
