Advances in roles of caspases in programmed cell death
10.7644/j.issn.1674-9960.2025.06.010
- VernacularTitle:胱天蛋白酶在程序性细胞死亡中作用机制研究进展
- Author:
Yuru HU
1
;
Zhan LI
;
Tao LI
;
Hui WANG
Author Information
1. 军事科学院军事医学研究院,病原微生物生物安全国家重点实验室,北京 100071
- Keywords:
caspase;
cell death;
apoptosis;
pyroptosis;
programmed necrosis
- From:
Military Medical Sciences
2025;49(6):465-472
- CountryChina
- Language:Chinese
-
Abstract:
The caspase family is a conserved cysteine protease with similar amino acid sequences,structures and enzyme characteristics.Caspase is a single polypeptide with a molecular weight of 30-50 kDa,which is composed of three domains:the N-terminal pre-domain,the large submit of 20 kDa and the small submit of 10 kDa.Programmed cell death plays a pivotal role in bodily immune responses to infections byclearing infected cells,activating immune responses of cells and regulating the balance of immune cells,so it is one of the important mechanisms through which the body resists pathogens.The activation and regulation of the caspase family are critical to programmed cell death.This article reviews the latest research progress in caspase activation and its mechanism in programmed cell death.
