Research progress in the regulation of pyroptosis pathways by the active components of traditional Chinese medicine
10.7644/j.issn.1674-9960.2025.04.011
- VernacularTitle:中药有效成分调节细胞焦亡途径研究进展
- Author:
Yanjiao YANG
1
;
Weina GAO
Author Information
1. 天津中医药大学,天津 301617;军事科学院军事医学研究院,天津 300050
- Keywords:
pyroptosis;
effective components of traditional Chinese medicine;
signaling pathways;
mechanism of action
- From:
Military Medical Sciences
2025;49(4):313-317
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis is a programmed cell death accompanied by cell swelling,nuclear condensation,membrane rup-ture,and the release of intracellular inflammatory factors.Pyroptosis is closely related to the occurrence and development of multiple organ and system diseases,and can trigger a cascade of inflammatory responses.Studies have demonstrated that effective components of traditional Chinese medicine(TCM)exhibit significant effects on modulating pyroptosis and the subsequent inflammatory responses.Here we review the research progress in studies on how TCM effective components improve diseases via pyroptosis in order to provide data for the development of new TCMs.
