Research progress in roles of endogenous metabolites in tumor progression and immune regulation
10.7644/j.issn.1674-9960.2025.04.010
- VernacularTitle:人体内源代谢物在肿瘤发展和免疫调节中的研究进展
- Author:
Haoqian ZHANG
1
;
Xin PAN
;
Yue QIAO
;
Chengrui XUAN
Author Information
1. 内蒙古医科大学基础医学院,呼和浩特 010110;军事科学院军事医学研究院,北京 100850
- Keywords:
metabolites;
tumor microenvironment;
amino acid;
lipid;
metabolism;
immunomodulation
- From:
Military Medical Sciences
2025;49(4):307-312
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic reprogramming in the tumor microenvironment is closely associated with tumor initiation and progression.Endogenous metabolites can not only regulate tumor formation and metastasis,but also impair antitumor immune efficacy by influencing immune cells.However,current research focuses on the effects of single metabolites on tumors rather than take into account the systemic nature of metabolic networks,the diversity of metabolic products,and their dynamic regulatory roles in the tumor immune microenvironment.An in-depth analysis of the key nodes in metabolic pathways related to endogenous metabolites and their regulatory mechanisms in tumor progression is crucial to the development of antitumor therapies based on metabolic intervention.This paper provides an overview of the molecular mechanisms by which endogenous metabolites,such as amino acids,lipids and nucleotides,contribute to tumor progression and regulate the immune microenvironment.By offering new theoretical insights into the complex network of the metabolism-immune axis in tumor development,this review aims to provide data for the development of metabolism-targeted antitumor immuno-therapy strategies.
