Effects of music therapy on cognition and immune function of mice
10.7644/j.issn.1674-9960.2025.04.005
- VernacularTitle:音乐理疗对小鼠认知及免疫功能的影响
- Author:
Yinji LIU
1
;
Chunxiao DU
;
Junrui CHEN
;
Yuxiang LI
;
Ge LI
;
Zhiding WANG
;
Gencheng HAN
Author Information
1. 军事科学院军事医学研究院,北京 100850;空军军医大学基础医学院,西安 710032
- Keywords:
music therapy;
IgA;
Morris water maze;
sleep deprivation;
learning and memory
- From:
Military Medical Sciences
2025;49(4):273-280
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of music therapy on cognitive function and immunity of sleep-deprived mice and the potential underlying mechanisms.Methods A novel music therapy was developed by integrating elements from both Western and Chinese music.A sleep-deprived mouse model was established to explore the effects of the music combination on learning and memory of mice using Morris water maze experiments.ELISA was used to detect immune-endocrine indicators in the blood and saliva of mice and to study the effects of this music combination on IgA levels.Transcriptome high-throughput sequencing and B-cell receptor(BCR)repertoire sequencing were adopted to explore the potential mechanisms through which music therapy influenced IgA production.Results The Morris water maze test revealed that the novel music therapy could promote the recovery of cognition and memory of sleep-deprived mice.Additionally,it was found that the music combination could increase IgA levels in both blood and saliva.Transcriptome high-throughput sequencing and BCR sequencing analysis showed that the music combination enhanced the abundance of the IgA immunoglobulin light chain variable region(Igkv4-53)and heavy chain constant region(Igha).Conclusion Music therapy can help restore cognitive function and increase IgA levels in sleep-deprived mice.The mechanism may be related to the enhanced abundance of immunoglobulin light chain variable region(Igkv4-53)and heavy chain constant region(Igha).
