Research progress in hypoxia inducible factors and body hypoxia tolerance
10.7644/j.issn.1674-9960.2025.03.011
- VernacularTitle:低氧诱导因子与机体低氧耐力的研究进展
- Author:
Zhaxi RENQING
1
;
Hao YANG
;
Rui WANG
;
Ya'nan LIANG
;
Ruiqing CHAI
;
Peiran ZHANG
;
Tongmei ZHANG
;
Xingcheng ZHAO
Author Information
1. 空军军医大学航空航天医学训练教研室,西安 710032
- Keywords:
hypoxia inducible factors;
hypoxia tolerance;
hypoxia adaption;
plateau
- From:
Military Medical Sciences
2025;49(3):233-238
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia inducible factors(HIFs)are core molecules that enable the body to adapt to hypoxia environments.By sensing changes in intracellular oxygen pressure,HIFs regulate gene expression related to hypoxia adaptation,thereby enhancing the body's hypoxia tolerance at cellular,tissue and organ levels.On the other hand,HIFs promote the generation of red blood cells,angiogenesis,and regulate the body's energy metabolism,thereby improving its hypoxia tolerance.The enhancement of hypoxia tolerance is of great significance for the prevention and treatment of hypoxia-related diseases,upgrading of athletes'performance,enhancement of workers'efficiency at high-altitudes,and the improvement of individu-als'quality of life.This article reviews the relationships between HIFs and hypoxia tolerance as well as related mechanisms in order to provide strategies for enhancing hypoxia tolerance in the body.
