Research progress in the relationship between anxiety,fear and immune inflammatory responses

VernacularTitle:焦虑、恐惧与免疫炎症反应关系的研究进展
Author: Dujuan HE ¹ ; Meikui ZHANG ; Han NI ; Jingyao DUAN ; Liming ZHANG
Author Information

1. 陕西中医药大学第一临床医学院,陕西咸阳 712046;军事医学研究院国家安全特需药品全国重点实验室,北京 100850;解放军总医院医疗保障中心远程医学科,北京 100853
Keywords: anxiety; fear; immune inflammation; stress
From: Military Medical Sciences 2025;49(3):227-232
CountryChina
Language:Chinese
Abstract: Anxiety and fear,as common symptoms of psychiatric disorders,remain inadequately understood in terms of their pathogenesis.Changes in immune inflammation are considered to play a significant role in both the pathological and physiological processes associated with these mental illnesses.In recent years,it has been demonstrated that stress can regulate immune inflammation through multiple pathways,including the regulation of the autonomic nervous system,the hypothalamic-pituitary-adrenal axis,indoleamine 2,3-dioxygenase and its metabolite kynurenine,and the gut-brain axis.These pathways are implicated in the onset and treatment of anxiety and fear-related mental illnesses.This article focuses on the relationships between anxiety and fear-related mental illnesses and immune inflammatory responses.