Protective effect of Gynostemma pentaphyllum on memory of individuals rapidly ascending to high altitudes
10.7644/j.issn.1674-9960.2025.03.005
- VernacularTitle:绞股蓝对急进高原人员记忆功能的保护作用
- Author:
Na MI
1
;
Weifeng WANG
;
Xiang CHENG
;
Ying ZHANG
;
Xiangpei YUE
;
Yifan ZHAO
;
Junli YANG
;
Lingling ZHU
Author Information
1. 军事科学院军事医学研究院,北京 100850
- Keywords:
Gynostemma pentaphyllum;
rapid ascent to high-altitudes;
hypoxia exposure;
working memory;
short-term memory;
memory span;
acute mountain sickness
- From:
Military Medical Sciences
2025;49(3):192-197
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of Gynostemma pentaphyllum on memory of individuals rapidly ascending to high altitudes.Methods Twenty-one healthy subjects were randomly divided into a G.pentaphyllum food group(n=12)and a control group(n=9).The first group consumed G.pentaphyllum food for seven consecutive days while the control group received placebos.Both groups ascended from the plains to an altitude of 3600 m.Memory function was assessed using the matching memory and sequential memory tests of a cognitive evaluation system on day 1 and day 7 on the plains,and at 24 and 48 h after ascending to the high altitude.Scores of acute mountain sickness symptoms were also recorded.Results After 24 h of stay at the high altitude,the score of headache of the G.pentaphyllum food group was significantly lower than that of the control group(P＜0.05).Cognitive test results showed that the matching memory accuracy and sequential memory accuracy of the control group at 24 and 48 h were significantly lower than those on the plains(P＜0.05).In contrast,the G.pentaphyllum food group performed significantly better than the control group in these metrics(P＜0.05).Conclusion Regular consumption of G.pentaphyllum food can effectively alleviate headache symptoms in individuals rapidly ascending to high altitudes and mitigate the decline in working memory,short-term memory,and memory spans caused by acute hypoxic exposure.
