Research progress of anti-Zika virus drug candidates
10.7644/j.issn.1674-9960.2025.01.009
- VernacularTitle:抗寨卡病毒候选药物研究进展
- Author:
Lidan ZHAO
1
;
Chao ZHANG
;
Lirong HAN
;
Donggang XU
Author Information
1. 军事认知与脑科学研究所,北京 100850;河北大学,河北保定 071002;河北大学公共卫生学院河北省公共卫生安全重点实验室,河北保定 071002
- Keywords:
Zika virus;
drug relocation;
small molecule antiviral drugs;
virus target;
host target
- From:
Military Medical Sciences
2025;49(1):54-60
- CountryChina
- Language:Chinese
-
Abstract:
Zika virus(ZIKV)is a mosquito-borne flavivirus associated with neurological complications such as Limbari syndrome in adults and microcephaly in newborns.As there are no drugs or preventive vaccines available to specifically treat ZIKV infection,there is an urgent need to take comprehensive measures to prevent and control ZIKV infection and stop its spread.In this paper,we reviewed the structure and function of ZIKV gene and protein,and summarized the progress in the development of virus-targeting anti-ZIKV drug candidates through high-throughput screening and drug relocation,and summarized the mechanism of action of virus and host cell targeting drug candidates.The research and development trend of small molecule antiviral drugs in the future is prospected,which provides reference for promoting the research and development of new anti-ZIKV drugs.
