Research progress in functions of deubiquitinating enzyme Mysm1
10.7644/j.issn.1674-9960.2024.12.010
- VernacularTitle:去泛素化酶Mysm1的功能研究进展
- Author:
Qiaozhen QIN
1
;
Xinlong YAN
;
Xiaoxia JIANG
Author Information
1. 北京工业大学化学与生命科学学院,北京 100124;军事科学院军事医学研究院,北京 100850
- Keywords:
deubiquitinase;
Mysm1;
stem cells;
immune cells;
cancer;
senescence;
depression
- From:
Military Medical Sciences
2024;48(12):946-950
- CountryChina
- Language:Chinese
-
Abstract:
As a deubiquitinating enzyme with important biological functions,Mysm1 has become a significant regulatory factor affecting the functions of various stem cells,immune responses and occurrence and development of multiple diseases.Studies have found that the sequences of mouse and human Mysm1 are highly homologous,both Mysm1 knockout mice and patients with Mysm1 gene mutations exhibit developmental disorders in multiple tissues and organs.Therefore,in-depth analysis of Mysm1 function in mouse models is critical to the etiological study of human Mysm 1-related syndromes.This article reviewed the various deubiquitinating functions of Mysm 1 in the nucleus or cytoplasm,its impact on the proliferation and differentiation of various stem cells and immune cell functions,its role in the occurrence and development of diseases such as cancer,aging and depression in hopes of providing a reference for in-depth research on Mysm1 in the future.
