Research progress in applicability of skeletal stem cells in military regenerative medicine

VernacularTitle:骨骼干细胞在军事再生医学中的应用价值研究进展
Author: Fuhao YU ¹ ; Li DING ; Heng ZHU
Author Information

1. 军事科学院军事医学研究院,北京 100850;空军军医大学研究生院,西安 710032;空军军医大学空军特色医学中心血液科,北京 100142
Keywords: skeletal stem cells; military regenerative medicine; bone fracture; osteochondral defect; radiation-induced bone injury
From: Military Medical Sciences 2024;48(12):940-945
CountryChina
Language:Chinese
Abstract: Military training and operations usually lead to such skeletal injuries as fatigue fractures,acute bone fractures,osteochondral defects,and radiation-induced bone injury.Skeletal stem cells(SSCs)are newly-identified innate tissue specific stem cells in skeletons which are capable of differentiating into bone,cartilage and bone marrow stromal tissues,and are one of the seed cells critical to the development,homeostasis,and regeneration of skeletons.SSCs are highly heterogenous in cellular subpopulations and spatiotemporal distributions,which is why their cellular immunopheto type and regenerative capacity are different in different anatomical sites.Thus,there is considerable difference in the response of SSCs to military injuries and in the underlying mechanisms.This review discussed the sources of SSCs,underlying mechanisms of SSCs-mediated skeletal regeneration,and the potential applications of SSCs in military regenerative medicine.