Analysis of the prevalence of New Delhi metallo-β-lactamase-positive drug-resistant bacteria in China from 2017 to 2023
10.7644/j.issn.1674-9960.2024.12.004
- VernacularTitle:我国2017-2023年新德里金属β-内酰胺酶阳性耐药菌流行现状分析
- Author:
Kexin LI
1
;
Yang XIAO
;
Mingliang CHEN
;
Shengshu WANG
;
Boqian WANG
;
Zhixi PENG
;
Shengnan LIANG
;
Hongguang REN
;
Hongbin SONG
;
Xiaofeng HU
Author Information
1. 中国医科大学,沈阳 110122;解放军疾病预防控制中心,北京 100071
- Keywords:
New Delhi metallo-β-lactamase;
epidemiological characteristics;
resistance profile
- From:
Military Medical Sciences
2024;48(12):907-913
- CountryChina
- Language:Chinese
-
Abstract:
Objective To comprehensively analyze the epidemiological characteristics and resistance mechanisms of New Delhi metallo-β-lactamase(NDM)-positive multidrug-resistant bacteria in China.Methods Relevant literatures on NDM-positive multidrug-resistant bacteria discovered in China were searched in the CNKI and PubMed databases(publications from January 1,2017 to December 31,2023).The epidemiological analysis was conducted on the types of NDM-positive bacterial strains,their regional distribution,infection sources,resistance profiles,and transfer mechanisms.Results A total of 118 eligible articles were collected,reporting 1627 NDM-positive bacterial strains.The number of reports increased annually from 2011 to 2019,but began to decline annually from 2020 onwards.NDM-1 and NDM-5 were the most commonly reported variants.The highest number of reports came from Eastern China,followed by Central China and North China.The primary pathogens were Klebsiella pneumoniae,Escherichia coli,and Enterobacter cloacae.The age distribution of patients with NDM-positive infections showed distinct patterns,with neonates and children accounting for 27.25％and patients over 50 years old accounting for 49.57％.The majority of positive bacterial infections came from sputum(38.28％),urine(28.94％),and blood(23.28％).The main departments reporting NDM-positive bacteria were the ICU(39.93％)and pediatrics(20.14％).These resistant bacteria exhibited resistance to more than 50.00％of antibiotics,with lower resistance to colistin and tigecycline(below 30.00％).The predominant plasmid type carrying the blaNDMwas IncX3,and the insertion sequences upstream and downstream of the blaNDM showed diversity.Conclusion NDM-positive multidrug-resistant bacteria are widely prevalent across regions in China,exhibiting multidrug-resistance.This poses significant challenges to clinical antibiotic selection and necessitates the development of effective countermeasures.
