Research progress of diabetes on chronic kidney disease mineral and bone metabolism disorders in maintenance hemodialysis patients
- VernacularTitle:糖尿病对维持性血液透析患者慢性肾脏病矿物质与骨代谢异常影响的研究进展
- Author:
Yu ZHOU
1
;
Rui YAN
;
Xingyan ZHOU
Author Information
- Keywords: chronic kidney disease; chronic kidney disease-mineral and bone disorder; fi-broblast growth factor 23; parathyroid hormone; diabetic nephropathy; vascular calcification; calci-um-phosphorus metabolism disorders; maintenance hemodialysis
- From: Journal of Clinical Medicine in Practice 2025;29(20):139-142,148
- CountryChina
- Language:Chinese
- Abstract: Chronic kidney disease(CKD)has a high prevalence rate.Its common complication,chronic kidney disease-mineral and bone disorder(CKD-MBD),has become an important factor af-fecting the long-term prognosis of patients.The pathogenesis of CKD-MBD is complex,involving mul-tiple mechanisms such as dysregulation of the Klotho-fibroblast growth factor 23(FGF23)-FGF recep-tor(FGFR)signaling pathway,calcium-phosphorus metabolism disorders,impaired synthesis of 1,25-dihydroxyvitamin D3[1,25-(OH)2D3],abnormal regulationof parathyroid hormone(PTH)secretion,and the involvement of the Wnt/β-catenin signaling pathway.Its pathological manifesta-tions not only include renal osteodystrophy but also involve in extraskeletal complications,such as vascular calcification and increased risk of cardiovascular events.Diabetes,as the most common cause of CKD,further exacerbates the development of CKD-MBD through various mechanisms,inclu-ding hyperglycemia,oxidative stress,activation of inflammatory factors,and bone microvascular dis-ease.In the population undergoing maintenance hemodialysis,there are differences in calcium-phos-phorus levels,PTH concentrations,and FGF23 expression patterns between diabetic nephropathy patients and non-diabetic CKD patients.However,the specific mechanisms underlying these changes have not been fully elucidated in large-scale epidemiological studies.This article aimed to review the basic research and clinical characteristics of CKD-MBD in diabetic nephropathy patients and non-diabetic CKD patients,with the hope of providing theoretical basis and practical guidance for future precision treatment.
