Value of Doppler ultrasound combined with serum mitochondrial fusion protein 2 and cavitary protein-1 in predicting fetal growth restriction in preeclampsia
- VernacularTitle:多普勒超声联合血清线粒体融合蛋白2与陷窝蛋白-1预测子痫前期胎儿生长受限的价值
- Author:
Ning ZHANG
1
;
Cuihong ZHAO
;
Guoying LEI
Author Information
- Keywords: fetal growth restriction; caveolin-1; mitofusin-2; placental function; preeclamp-sia; vascular endothelial dysfunction; Doppler ultrasound parameters; receiver operating characteris-tic curve
- From: Journal of Clinical Medicine in Practice 2025;29(20):134-138
- CountryChina
- Language:Chinese
- Abstract: Objective To analyze the predictive value of Doppler ultrasound parameters com-bined with serum mitofusin-2 and caveolin-1(Cav-1)levels in pregnant women with preeclampsia for fetal growth restriction.Methods A total of 167 pregnant women with preeclampsia were selected as the study subjects and divided into fetal growth restriction group(n=63)and non-fetal growth re-striction group(n=104).Enzyme-linked immunosorbent assay(ELISA)was used to measure the serum levels of mitofusin-2 and Cav-1 in both groups.Multivariate logistic regression analysis was em-ployed to screen for influencing factors of fetal growth restriction.The receiver operating characteristic(ROC)curve was utilized to evaluate the predictive value of Doppler ultrasound parameters combined with serum mitofusin-2 and Cav-1 levels for fetal growth restriction.Results The gestational age at delivery in the fetal growth restriction group was significantly shorter than that in the non-fetal growth restriction group(P＜0.05).The serum levels of mitofusin-2 and Cav-1 in the fetal growth restriction group were significantly lower than those in the non-fetal growth restriction group(P＜0.05).The Doppler ultrasound parameters[umbilical artery peak systolic velocity/umbilical artery end-diastolic velocity(S/D),resistance index(RI)and pulsatility index(PI)]in the fetal growth restriction group were significantly higher than those in the non-fetal growth restriction group(P＜0.05).Multivariate logistic regression analysis revealed that gestational age at delivery,as well as the levels of mitofusin-2 and Cav-1 were influencing factors for fetal growth restriction(P＜0.05).The area under the curve(AUC)for the combined prediction of fetal growth restriction using S/D,RI,PI,mitofusin-2 and Cav-1 was superior to that of each individual indicator.Conclusion The AUC for predicting fetal growth restriction using Doppler ultrasound parameters combined with serum mitofusin-2 and Cav-1 levels in pregnant women with preeclampsia is 0.960,providing a clinically operable tool for early risk stratification of fetal growth restriction.
