Clinical efficacy and mechanism of Xuanbi Decoction as an adjuvant therapy for rheumatoid arthritis with dampness-heat obstruction syndrome
- VernacularTitle:宣痹汤辅助治疗湿热痹阻证类风湿性关节炎的临床疗效与作用机制研究
- Author:
Cuiping WANG
1
;
Yi LIANG
;
Wenjing YU
;
Hu SHA
;
Songmiao CHENG
;
Min LI
Author Information
- Keywords: rheumatoid arthritis; dampness-heat obstruction syndrome; Xuanbi Decoction; interleukin-23; helper T cell 17; matrix metalloproteinase-3; tissue inhibitor of metalloproteinase-1; adverse reactions
- From: Journal of Clinical Medicine in Practice 2025;29(19):83-88
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the efficacy of Xuanbi Decoction as an adjuvant therapy for rheumatoid arthritis(RA)with dampness-heat obstruction syndrome,and its impacts on the interleu-kin-23(IL-23)/helper T cell 17(Th 17)inflammatory axis,as well as the levels of matrix metallo-proteinase-3(MMP-3)and tissue inhibitor of metalloproteinase-1(TIMP-1).Methods A total of 95 RA patients with dampness-heat obstruction syndrome were selected as the study subjects,and randomly divided into control group(48 cases)and observation group(47 cases).The control group received western medicine treatment,while the observation group received Xuanbi Decoction treat-ment based on the control group.The clinical efficacy,traditional Chinese medicine(TCM)syn-drome scores,imaging assessment results,disease activity,indicators of the IL-23/Th17 inflammatory axis,MMP-3,TIMP-1 and adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 95.74％,which was significantly higher than 81.25％in the control group(P＜0.05).After treatment,the TCM syndrome scores(joint pain,joint swell-ing,yellow and greasy tongue coating as well as slippery and rapid pulse)in the observation group were significantly lower than those in the control group(P＜0.05).After treatment,the DAS28 and Sharp scores in the observation group were significantly lower than those in the control group(P＜0.05).After treatment,the levels of IL-23,Th17,IL-17 and MMP-3 in the observation group were significantly lower than those in the control group,while the TIMP-1 level was significantly higher(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Xuanbi Decoction as an adjuvant therapy for RA patients with dampness-heat obstruction syndrome demonstrates significant efficacy and high safety.
