Association of peripheral blood intermediate monocyte subset with prognosis in acute myocardial infarction patients receiving percutaneous coronary intervention
- VernacularTitle:外周血中间型单核细胞亚群与接受经皮冠状动脉介入治疗的急性心肌梗死患者预后的关系
- Author:
YUSHANJIANG PALIDA
1
;
AISIKAER GULISTAN
;
Yiping MA
;
ALIMU NIGERE
;
YISTIMILA TUERSUNAYI
;
NIJIATI MUYESAI
Author Information
- Keywords: intermediate monocyte subset; acute myocardial infarction; percutaneous coro-nary intervention; major adverse cardiovascular events; prognostic assessment; Cox regression analy-sis; Kaplan-Meier survival analysis; monocyte subset analysis
- From: Journal of Clinical Medicine in Practice 2025;29(19):31-36
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the association between the proportion of peripheral blood intermediate monocyte subset(Mon2)and prognosis in patients with acute myocardial infarction(AMI)receiving percutaneous coronary intervention(PCI).Methods A total of 100 AMI patients who underwent PCI between March 2021 and June 2022 were enrolled.Peripheral venous blood sam-ples were collected within 24 hours of onset in all patients,and monocyte subsets were analyzed using three-color flow cytometry.Patients were followed up for at least 1 year after discharge,and major ad-verse cardiovascular events(MACE)were recorded.Results The optimal cut-off point for predic-ting MACE occurrence 1 year after PCI in AMI patients based on the Mon2 proportion was 25.65％(area under the curve=0.758,95％CI,0.607 to 0.909,P=0.002),with a sensitivity of 64.3％and a specificity of 86.0％.Patients were divided into high Mon2 proportion group and low Mon2 proportion group according to the optimal cut-off value.There were significant differences in globu-lin,creatinine,fasting blood glucose,left ventricular end-systolic diameter,and Mon2 proportion between the two groups(P＜0.05).After adjusting for potential confounding factors using Cox re-gression,Mon2 proportion was found to be an important indicator for predicting poor prognosis after AMI.Kaplan-Meier survival analysis showed that the Mon2 proportion had a significant impact on the incidence of MACE in AMI patients with different risk stratifications.Conclusion Mon2 can improve the accuracy of predicting MACE after PCI,providing a new perspective for prognostic as-sessment in AMI patients.It is helpful for guiding clinical treatment decisions and improving patient prognosis.
