Application of dexmedetomidine in perioperative period of aortic root reconstruction surgery
- VernacularTitle:右美托咪定在主动脉根部重建手术围术期的应用研究
- Author:
Fan LI
1
;
Yuanting GUO
;
Xiaoyu ZHOU
;
Chen HUANG
Author Information
- Keywords: aortic root reconstruction surgery; dexmedetomidine; postoperative delirium; at-rial fibrillation; cardiopulmonary bypass; left ventricular ejection fraction; aortic cross-clamping time; allogeneic red blood cell transfusion
- From: Journal of Clinical Medicine in Practice 2025;29(19):6-11
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the effect of 24-hour perioperative application of dexme-detomidine on the occurrence of postoperative atrial fibrillation and delirium in patients undergoing aortic root reconstruction.Methods A total of 600 patients scheduled for elective cardiac surgery under cardiopulmonary bypass were selected as the study subjects.Eventually,584 patients were in-cluded in the randomized grouping,with 292 patients in treatment group and 292 patients in control group.The treatment group received dexmedetomidine treatment,while the control group received sa-line placebo treatment.The occurrence of atrial fibrillation and delirium events,as well as other clini-cal indicators,in the two groups of patients within 5 days after surgery were observed,and the differ-ences in atrial fibrillation and delirium events among different subgroups were analyzed.Results The incidence rates of atrial fibrillation and delirium events within 5 days postoperatively in the treatment group were lower than those in the control group,with statistically significant differences(P＜0.05).Subgroup analysis showed that for atrial fibrillation events,dexmedetomidine had a protective effect when the cardiopulmonary bypass time was＞180 min,the aortic cross-clamping time was＞120 min.For delirium events,dexmedetomidine had a protective effect when the cardiopulmonary bypass time was ≤180 min,the aortic cross-clamping time was ≤120 min,there was no significant increase in creatinine,no significant decrease in left ventricular ejection fraction(LVEF),the European System for Cardiac Operative Risk Evaluation Ⅱ score at low risk,and the allogeneic red blood cell transfu-sion volume was ≤2 U.Conclusion The 24-hour perioperative application of dexmedetomidine in-patients undergoing aortic root reconstruction can reduce the incidence of postoperative atrial fibrilla-tion and delirium.
