Research progress on the biological characteristics of soluble receptor for advanced glycation end-products in infection-related pulmonary diseases
- VernacularTitle:可溶性晚期糖基化终产物受体在感染相关肺部疾病生物学特性的研究进展
- Author:
Dongning YAN
1
;
Xiaojun CHEN
;
Changling LI
;
Keru ZHANG
Author Information
- Keywords: soluble receptor for advanced glycation end-products; pulmonary infection; inflam-matory response; pattern recognition receptor; biological marker; cellular signaling pathway; pneumo-nia microorganisms; community-acquired pneumonia
- From: Journal of Clinical Medicine in Practice 2025;29(18):137-141,148
- CountryChina
- Language:Chinese
- Abstract: Pulmonary infection is one of the infectious diseases that have long plagued human health.The receptor for advanced glycation end-products(RAGE)is a non-specific,multi-ligand pat-tern recognition receptor expressed on the surface of various tissues and cells.It can bind to a series of structurally different ligands,including pathogen-associated molecular patterns from pathogenic micro-organisms.Soluble receptor for advanced glycation end-products(sRAGE)is a soluble form generated when cell surface RAGE is excessively stimulated by inflammatory cytokines.As a competitive recep-tor,it inhibits multiple RAGE-dependent cellular signaling pathways and participates in the inflamma-tory response process.This review summarized the clinical significance of serum sRAGE levels in in-fection-related pulmonary diseases,explored the biological characteristics of sRAGE in these diseases,and evaluated its clinical application value.
