Correlations of interleukin-1β level and percentage of CD16+CD56+natural killer cells in peripheral blood with severity of disease in patients with pulmonary tuberculosis
- VernacularTitle:肺结核患者外周血白细胞介素-1β及CD16+CD56+自然杀伤细胞百分比水平与病情的相关性分析
- Author:
Ling YUAN
1
;
Tiantian ZHANG
;
Weiwei GAO
;
Hongmei JIANG
Author Information
- Keywords: pulmonary tuberculosis; interleukin-1β; cluster of differentiation; natural killer cells; latent tuberculosis infection; active pulmonary tuberculosis disease
- From: Journal of Clinical Medicine in Practice 2025;29(18):102-105
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the correlations of interleukin-1 β(IL-1β)level and per-centage of CD16+CD56+natural killer(NK)cells in peripheral blood with severity of disease in pa-tients with pulmonary tuberculosis.Methods A total of 150 patients with active pulmonary tubercu-losis(APTB)in the Suqian First People's Hospital from January 1,2021 to September 1,2023 were selected as APTB group,and 150 patients with inactive pulmonary tuberculosis(IPTB)in the same period were selected as IPTB group.Level of IL-1 β and percentage of CD16+CD56+NK cells in pe-ripheral blood of patients with different disease severities were compared,and their correlations with severity of disease were analyzed.Results In the APTB group,level of IL-1 β in the peripheral blood was significantly higher than that in the IPTB group,while the percentage of CD16+CD56+NK cells was significantly lower(P＜0.001).In the mild,moderate,and severe groups,level of IL-1 βshowed a significant gradual increasing trend in peripheral blood,while the percentage of CD16+CD56+NK cells showed a significant gradual decreasing trend(P＜0.001).After treatment,the level of IL-1β in the peripheral blood decreased significantly,while the percentage of CD16+CD56+NK cells increased significantly in the APTB group(P＜0.001).Correlation analysis revealed that level of IL-1β in the peripheral blood of patients with pulmonary tuberculosis was positively correlated with severity of disease(r=0.732,P＜0.001),while the percentage of CD16+CD56+NK cells was negatively correlated with severity of disease(r=-0.612,P＜0.001).Conclusion Level of IL-1β in the peripheral blood is elevated while the percentage of CD16+CD56+NK cells is de-creased in patients with pulmonary tuberculosis,which is closely related to the severity of APTB.
