Predictive value of serum macrophage migration inhibitory factor,monocyte chemoattractant factor-1 levels combined with capillary leak index for acute respiratory distress syndrome in patients with sepsis
- VernacularTitle:血清巨噬细胞移动抑制因子、单核细胞趋化因子-1水平联合毛细血管渗漏指数对脓毒症患者并发急性呼吸窘迫综合征的预测价值
- Author:
Xue ZHAN
1
;
Hao WANG
Author Information
- Keywords: macrophage migration inhibitory factor; monocyte chemoattractant factor-1; cap-illary leak index; sepsis; acute respiratory distress syndrome; oxygenation index; Acute Physiology and Chronic Health Evaluation Ⅱ score; Sequential Organ Failure Assessment sco
- From: Journal of Clinical Medicine in Practice 2025;29(18):1-5,13
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the predictive value of serum macrophage migration inhibi-tory factor(MIF),monocyte chemoattractant factor-1(MCP-1)levels combined with capillary leak index(CLI)for acute respiratory distress syndrome(ARDS)in patients with sepsis.Methods A total of 212 patients with sepsis were selected as the study subjects.Their clinical manifestations,chest X-ray plain film,and CT scan results were observed.The patients were divided into ARDS group(62 cases)and non-ARDS group(150 cases).The serum MIF and MCP-1 levels and CLI of the two groups were compared.Multivariate logistic regression analysis was used to screen the influencing fac-tors for ARDS in patients with sepsis.The receiver operating characteristic(ROC)curve was em-ployed to evaluate the predictive efficacy of relevant indicators for ARDS in patients with sepsis.Results The serum MIF and MCP-1 levels and CLI in the ARDS group were all higher than those in the non-ARDS group,with statistically significant differences(P＜0.05).The oxygenation index in the ARDS group was lower than that in the non-ARDS group,while the Acute Physiology and Chron-ic Health Evaluation Ⅱ(APACHE Ⅱ)score and Sequential Organ Failure Assessment(SOFA)score were higher than those in the non-ARDS group,with statistically significant differences(P＜0.05).Multivariate logistic regression analysis showed that a low oxygenation index,high APACHE Ⅱscore,high SOFA score,high serum MIF level,high serum MCP-1 level,and high CLI were all in-dependent risk factors for ARDS in patients with sepsis(P＜0.05).The ROC curve demonstrated that the areas under the curve(AUCs)for predicting ARDS in patients with sepsis by MIF,MCP-1,and CLI alone and their combination were 0.902,0.818,0.708,and 0.932,respectively.The combined prediction had the highest efficacy,with a sensitivity of 96.77％and a specificity of 96.67％.Conclusion Serum MIF and MCP-1 levels and CLI are all closely related to ARDS in patients with sepsis.The combined application of these three indicators has a high predictive value for ARDS in patients with sepsis.
