Advances in relationships of tumor-infiltrating lymphocytes and microsatellite status with prognosis in colorectal cancer
- VernacularTitle:结直肠癌肿瘤浸润淋巴细胞及微卫星状态与预后关系的研究进展
- Author:
Qingqing WEI
1
;
Ningyi LIU
;
Yiran ZHANG
;
Anliang HUANG
;
Fan YANG
Author Information
- Keywords: tumor-infiltrating lymphocytes; microsatellite instability; colorectal cancer; tumor microenvironment; mismatch repair deficiency; immune checkpoint inhibitors; targeted therapy; prognosis
- From: Journal of Clinical Medicine in Practice 2025;29(17):138-143
- CountryChina
- Language:Chinese
- Abstract: Colorectal cancer is one of the most prevalent malignant tumors in the digestive system globally,with both its incidence and mortality showing an upward trend.In recent years,immunother-apy has become a research focus in the prognosis of CRC.Different states of tumor-infiltrating lym-phocytes(TILs)in patients have distinct impacts on tumor progression.The diversity of TILs and their interactions among cells reflect the complex relationship between tumors and the immune system.Patients with mismatch repair-deficient and microsatellite instability-high(dMMR/MSI-H)molecular phenotypes exhibit higher levels of TILs.Moreover,immune checkpoint inhibitors(ICIs),which are relevant targeted drugs for immune checkpoint blockade,also demonstrate a higher response rate in colorectal cancer patients with dMMR/MSI-H molecular phenotypes.This article reviewed the basic characteristics and prognostic value of TILs,as well as the relationship between dMMR/MSI-H and the immunological characteristics of colorectal cancer patients.
