Research progress on correlation between non-high-density lipoprotein cholesterol and complications of type 2 diabetes mellitus
- VernacularTitle:非高密度脂蛋白胆固醇与2型糖尿病并发症相关性研究进展
- Author:
Junhan ZHANG
1
;
Honghua WEN
;
Zhixiong PAN
;
Qun ZHU
Author Information
- Keywords: non-high-density lipoprotein cholesterol; type 2 diabetes mellitus; dyslipidemia; cardiovascular disease; atherosclerotic cardiovascular disease; diabetic complications; retinopathy; chronic kidney disease
- From: Journal of Clinical Medicine in Practice 2025;29(17):133-137
- CountryChina
- Language:Chinese
- Abstract: Dyslipidemia is one of the common metabolic disorders in type 2 diabetes mellitus,often coexisting with insulin resistance and central obesity to form metabolic syndrome,significantly increasing the risk of macrovascular and microvascular complications in diabetic patients.Non-high-density lipoprotein cholesterol(non-HDL-C)refers to the sum of cholesterol contained in other lipopro-teins except high-density lipoprotein cholesterol(HDL-C).In recent years,the importance of non-HDL-C in the management of diabetic complications has garnered increasing attention,and it has been established as a major lipid-lowering target along with low-density lipoprotein cholesterol(LDL-C)in the latest expert consensus on lipid management for Chinese diabetic patients.Clinical studies have demonstrated that non-HDL-C is closely associated with residual cardiovascular risk and recurrent stroke risk in diabetic patients,as well as carotid plaque vulnerability and the development of peripher-al arterial disease.Additionally,non-HDL-C is also closely related to diabetic nephropathy and reti-nopathy in type 2 diabetes mellitus,and achieving long-term control of non-HDL-C levels can reduce the risk of chronic kidney disease.This article summarized the relationship between non-HDL-C and complications of type 2 diabetes mellitus and elucidated its significance as a future clinical therapeutic target.
