Research progress on function and mechanism of ubiquitin-specific protease 11 in tumorigenesis and development
- VernacularTitle:泛素特异性蛋白酶11在肿瘤发生发展中的功能机制研究进展
- Author:
Caimin LI
1
;
Jiajia LI
;
Sicong HOU
;
Xuefeng GAO
Author Information
- Keywords: ubiquitin-specific protease 11; deubiquitination; substrate; tumor; cell prolifera-tion; cell death; tumor metastasis; drug resistance
- From: Journal of Clinical Medicine in Practice 2025;29(17):126-132
- CountryChina
- Language:Chinese
- Abstract: Ubiquitination is a crucial post-translational modification that is extensively involved in the regulation of protein activity,signal transduction,and the maintenance of genomic stability.As an important member of the deubiquitinating enzyme(DUB)family,ubiquitin-specific protease 11(USP11)dynamically regulates the stability and function of key tumor proteins by targeting specific substrates for deubiquitination.This,in turn,influences various biological behaviors of tumor cells,including proliferation,apoptosis,migration,invasion,metastasis,and drug resistance,ultimately exhibiting a dual role in either promoting or inhibiting cancer.This article systematically reviewed the relevant research progress on the role of USP11 in tumorigenesis and development and provided an in-depth analysis of the specific mechanisms by which USP11 participates in cellular biological behav-iors,aiming to offer a theoretical basis for the future development of small-molecule inhibitors targeting USP11,the formulation of combination drug strategies,and the identification of effective biomarkers.
