The role and application of intestinal microecology in immune regulation of tuberculosis
- VernacularTitle:肠道微生态在结核病免疫调节中的作用与应用
- Author:
Gaofeng PAN
1
;
Hongdan LIU
;
Xian ZHENG
;
Hua YANG
;
Maoying FU
Author Information
- Keywords: tuberculosis; intestinal microecology; immune regulation; gut-lung axis; intesti-nal microbiota modulators; short-chain fatty acids; microbiota transplantation; targeted intervention
- From: Journal of Clinical Medicine in Practice 2025;29(17):120-125
- CountryChina
- Language:Chinese
- Abstract: Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis,pri-marily transmitted through respiratory droplets,and poses a significant global public health challenge.Despite the availability of vaccines and chemotherapy regimens,the emergence of drug resistance and high incidence rates continue to render the prevention and control situation severe.The intestinal mi-crobiota modulates host immunity through metabolites such as short-chain fatty acids,influencing macrophage function,T-cell differentiation,and inflammatory responses,thereby regulating tubercu-losis susceptibility,disease progression,and treatment responses.This review systematically summa-rized the role of intestinal microecology in immune regulation of tuberculosis and its potential applica-tion strategies,delved into the possible immune regulatory mechanisms,proposed that the interaction between intestinal microbiota and immune checkpoint inhibitors may serve as a warning for the clinical risk of tuberculosis reactivation,and analyzed the potential of intestinal microecology as a therapeutic target for tuberculosis.
