Cytokine levels and clinical significance in patients with inflammatory bowel disease complicated by active tuberculosis following anti-tumor necrosis factor-α therapy
- VernacularTitle:抗肿瘤坏死因子-α治疗炎症性肠病继发活动性结核病患者的细胞因子水平及临床意义
- Author:
Xiaoyang LI
1
;
Guizeng ZHAO
;
Xia WANG
Author Information
- Keywords: inflammatory bowel disease; active tuberculosis; anti-tumor necrosis factor-α monoclonal antibody; interferon-γ; interleukin-1 receptor antagonist; interleukin-2; interleukin-10; cytokine
- From: Journal of Clinical Medicine in Practice 2025;29(17):90-94
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the cytokine levels and their clinical significance in pa-tients with inflammatory bowel disease(IBD)complicated by active tuberculosis(ATB)following an-ti-tumor necrosis factor-α(TNF-α)therapy.Methods A retrospective study was conducted in 92 patients with IBD complicated by latent tuberculosis infection.The patients were divided into observa-tion group(37 cases)and control group(55 cases)based on whether they developed ATB.Enzyme-linked immunosorbent assay(ELISA)was used to measure serum cytokine levels,including interfer-on-γ(IFN-γ),interleukin-1 receptor antagonist(IL-1Ra),interleukin-2(IL-2),interleukin-4(IL-4),interleukin-10(IL-10)and interleukin-17(IL-17).Spearman correlation analysis was per-formed to evaluate the associations between cytokine levels and the risk of secondary ATB.Multivari-ate Logistic regression analysis was used to identify the influencing factors for development of ATB in IBD patients treated with anti-TNF-α therapy.Receiver operating characteristic(ROC)curves were plotted to evaluate the predictive value of cytokines for the development of ATB.Results The levels of IFN-γ,IL-1Ra,IL-2 and IL-10 in the observation group were significantly higher than those in the control group(P＜0.05).The levels of IL-4 and IL-17 in the observation group were slightly higher than those in the control group,but the differences were not statistically significant(P＞0.05).Positive correlations were observed between the levels of IFN-γ,IL-1Ra,IL-2 and IL-10 and the risk of secondary ATB(r=0.737,0.586,0.660 and 0.619,respectively;P＜0.05).Serum levels of IFN-γ,IL-1Ra,IL-2 and IL-10 were all independent influencing factors for the de-velopment of ATB in IBD patients treated with anti-TNF-α therapy(P＜0.05).ROC curve analysis revealed that the combination of IFN-γ,IL-1Ra and IL-10 had the highest predictive efficacy for the development of ATB in IBD patients treated with anti-TNF-α therapy,with an area under the curve of 0.996.Conclusion The serum levels of IFN-γ,IL-1Ra,IL-2 and IL-10 are significantly ele-vated in IBD patients complicated by ATB following anti-TNF-α therapy.These cytokines are all in-dependent influencing factors for the development of ATB,and the combination of IFN-γ,IL-1Ra and IL-10 demonstrates the highest predictive efficacy.
