Expression levels and clinical significance of microRNA-152-3p and sex determining region-box transcription factor 5 in gastric cancer tissues
- VernacularTitle:胃癌组织中微小RNA-152-3p和性别决定区Y-box蛋白5的表达水平及临床意义
- Author:
Shuli GUO
1
;
Chen YANG
;
Dan LU
;
Xiaomin GUO
;
Shuhua GUO
;
Xinfeng HAN
Author Information
- Keywords: gastric cancer; microRNA-152-3p; sex determining region-box transcription fac-tor 5; clinicopathological characteristics; prognosis; lymph node metastasis; epithelial-mesenchymal transition; Kaplan-Meier survival curve
- From: Journal of Clinical Medicine in Practice 2025;29(17):33-37
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the expression levels of microRNA-152-3p(miR-152-3p)and sex determining region-box transcription factor 5(SOX5)in gastric cancer(GC)tissues and their clinical significance.Methods A total of 120 GC patients were selected as study subjects.Re-al-time quantitative polymerase chain reaction(qRT-PCR)was used to detect the expression levels of miR-152-3p and SOX5,and their relationships with the clinicopathological characteristics of GC pa-tients were analyzed.The Kaplan-Meier method was applied to draw survival curves,and the Cox re-gression model was used to screen the prognostic influencing factors of GC patients.Results The ex-pression level of miR-152-3p in GC tissues was lower than that in adjacent non-cancerous tissues,while the expression level of SOX5 was higher than that in adjacent non-cancerous tissues(P＜0.05).The expressions of miR-152-3p and SOX5 in GC tissues were all associated with lymph node metastasis,degree of differentiation,and TNM stage(P＜0.05).The expression level of miR-152-3p was negatively correlated with that of SOX5(r=-0.512,P＜0.05),and there were targeted binding sites between miR-152-3p and SOX5.The 5-year specific survival rate of the low miR-152-3p expression group was lower than that of the high miR-152-3p expression group(60.53％versus 84.09％,x2=7.256,P＜0.05).The 5-year specific survival rate of the high SOX5 expression group was 63.10％,which was lower than 83.33％of the low SOX5 expression group,with a statis-tically significant difference(x2=4.840,P＜0.05).Multivariate Cox regression analysis showed that the expression levels of miR-152-3p and SOX5,as well as the TNM stage,were all independent prog-nostic influencing factors for GC patients(P＜0.05).Conclusion Low expressions of miR-152-3p and high expression of SOX5 are observed in GC tissues,and their expression levels are closely re-lated to clinicopathological characteristics such as TNM stage and patients' prognosis.
