Multifunctional regulatory mechanisms and therapeutic translation of G protein-coupled receptor 17 in central nervous system
- VernacularTitle:G蛋白耦联受体17在中枢神经系统的多功能调控机制及治疗转化
- Author:
Anping HONG
1
;
Qi ZHANG
;
Xiaobo SUN
Author Information
- Keywords: G protein-coupled receptor 17; oligodendrocyte; microglia; neural regeneration; glioma; metabolic regulation; signal transduction; therapeutic target
- From: Journal of Clinical Medicine in Practice 2025;29(16):134-141
- CountryChina
- Language:Chinese
- Abstract: G protein-coupled receptor 17(GPR17)is a G protein-coupled receptor whose func-tional diversity is regulated by multiple mechanisms,including receptor dimerization and epigenetic modifications.It is involved in the development of the nervous system,injury repair,and the progres-sion of various neurological diseases.This study integrated a three-dimensional functional network of neurodevelopment-injury repair-metabolic regulation to elucidate the normal developmental process and pathological progression of GPR17 in the nervous system.In the nervous system,GPR17 partici-pates in the fate regulation of oligodendrocyte lineage cells and the activation of microglia,and also affects the pluripotency regulation of neural precursor cells and adult neural tissues.Under neuro-pathological conditions such as demyelinating diseases,brain injuries,and gliomas,GPR17 expres-sion is abnormal.Inhibiting its expression can alleviate myelin sheath damage,while activating its ex-pression can induce the differentiation and apoptosis of glioma cells.Additionally,GPR17 is involved in the regulation of metabolism,aging,and cognitive dysfunction.Although significant progress has been made in current research,the signal transduction mechanisms during development and the spe-cific action pathways in neurological diseases still require further exploration.Given the multifunction-ality and key role of GPR17 in the nervous system,this field holds promise for providing novel ideas and therapeutic strategies for neural development,injury repair,and the treatment of related diseases.
