Mediating effect of disturbance of consciousness and neutrophil-to-lymphocyte ratio on stroke-associated pneumonia in patients with different degrees of neurological dysfunction
- VernacularTitle:意识水平和中性粒细胞与淋巴细胞比值对不同程度神经功能缺损患者发生卒中相关性肺炎的中介效应分析
- Author:
Jiaxin JIN
1
;
Pengzhen MA
;
Tingting CHEN
;
Yingzhen XIE
Author Information
- Keywords: stroke; stroke-associated pneumonia; fasting blood glucose; neutrophil-to-lym-phocyte ratio; mediation analysis; influencing factors; inflammatory markers; degree of neurological deficit
- From: Journal of Clinical Medicine in Practice 2025;29(16):1-8,13
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the mediating effects of potential mediating factors on occur-rence of stroke-associated pneumonia(SAP)in patients with varying degrees of neurological deficit based on real-world case data.Methods A total of 902 hospitalized patients in the acute phase of stroke were selected as study subjects.Clinical characteristics were compared among patients with dif-ferent degrees of neurological deficit and those with SAP.R studio was employed to generate a correla-tion heatmap of potential mediating factors,enabling the identification of primary potential mediating factors.Multivariate logistic regression analysis was conducted to assess the impact of the degree of neurological deficit,potential mediating factors,and stroke-associated pneumonia.R studio was also used to analyze the interaction between the degree of neurological deficit and potential mediating factors,as well as the mediating role of potential mediating factors in the association between neurological deficit and SAP.Results Based on the results of the correlation heatmap,this study screened out five major potential mediating factors,namely consciousness level,neutrophil-to-lymphocyte ratio(NLR),chlorine(Cl),fasting blood glucose(FBG)and albumin(ALB).Multivariate logistic re-gression analysis revealed that the degree of neurological deficit was significantly associated with the level of consciousness,NLR,Cl,FBG levels and the occurrence of SAP.Interaction analysis dem-onstrated an interaction between the degree of neurological deficit and FBG levels.Mediation analy-sis indicated that the total effect of the association between neurological deficit and SAP was 0.302.Both the level of consciousness and NLR exhibited partial mediating effects in the association be-tween neurological deficit and SAP,with mediating effect proportions of 25.92％and 15.15％,re-spectively.Conclusion Consciousness level and NLR have partial mediating effects in the occur-rence of SAP in patients with different neurological deficits.There is an interaction between the de-gree of neurological deficit and the level of FBG.
