Summary of best available evidence on pharmacological prophylaxis for pregnancy-associated venous thromboembolism
- VernacularTitle:妊娠相关静脉血栓药物预防的最佳证据总结
- Author:
Chenshi LI
1
;
Wanqing LI
;
Zhaofeng XUE
;
Yicheng LI
;
Yucheng WANG
;
Wei ZHOU
Author Information
- Keywords: venous thromboembolism; pharmacological prophylaxis; pregnancy; evidence-based medicine; evidence summary; drug contraindications; prophylactic strategies; pregnancy out-comes
- From: Journal of Clinical Medicine in Practice 2025;29(15):63-71
- CountryChina
- Language:Chinese
- Abstract: Objective To search,analyze,and summarize the best available evidence on phar-macological prophylaxis for pregnancy-associated venous thromboembolism(PA-VTE).Methods Uti-lizing evidence-based medicine methodologies,a computerized search was conducted for all evidence pertaining to pharmacological prophylaxis of PA-VTE,including guidelines,expert consensus,sys-tematic reviews,clinical decisions,evidence summaries,and recommended practices.The time for the search ranged from the establishment of relevant databases up to December 13,2024.Two re-searchers independently assessed the quality of the included literature.In cases of disagreement,a third researcher was consulted to reach a consensus on the final evaluation.Results A total of 20 arti-cles were included,comprising 6 guidelines,7 systematic reviews,2 clinical decisions,3 expert consensus documents,and 2 evidence summaries.From seven aspects including drug types,drug selection,drug contraindications,timing of prophylactic medication,prophylactic strategies and implementation plans,medication precautions,and health education,28 pieces of evidence were summarized.Con-clusion This study has compiled the best available evidence on pharmacological prophylaxis for PA-VTE,which can guide healthcare professionals inproviding individualized pharmacological prophylaxis strategies for pregnant women,thereby reducing the incidence of venous thromboembo-lism and improving pregnancy outcomes.
