Value of human papillomavirus E6/E7 mRNA combined with colposcopy in screening cervical cancer and precancerous lesions
- VernacularTitle:人乳头瘤病毒E6/E7 mRNA联合阴道镜检查在宫颈癌及癌前病变筛查中的价值
- Author:
Lingyun XIE
1
;
Hongmei LU
;
Yang XU
;
Ling LING
;
Jing YIN
;
Jing YANG
;
Wenguo CHENG
Author Information
- Keywords: cervical precancerous lesions; cervical cancer; human papillomavirus; colpos-copy; diagnostic efficacy; clinical screening; squamous intraepithelial lesions; cervical squamous cell carcinoma
- From: Journal of Clinical Medicine in Practice 2025;29(15):47-51,57
- CountryChina
- Language:Chinese
- Abstract: Objective To evaluate the efficacy of human papillomavirus E6/E7(HPV E6/E7)mRNA combined with colposcopy in screening cervical cancer and precancerous lesions.Methods A total of 480 patients with suspected cervical precancerous lesions in the hospital from July 2022 to De-cember 2024 were retrospectively selected as research objects.All the patients underwent HPV E6/E7 mRNA testing,colposcopy,and pathological examination.Taking the pathological examination results as the diagnostic golden standard,the diagnostic values of HPV E6/E7 mRNA and colposcopy alone as well as their combination were analyzed.Results The pathological examination results of 480 pa-tients showed that there were 192 negative cases,including 1 case of normal cervix and 191 cases of benign lesions;there were 288 positive cases,including 133 cases of low-grade squamous intraepithe-lial lesions(LSIL),110 cases of high-grade squamousintraepithelial lesions(HSIL),and 45 cases of cervical squamous cell carcinoma(SCC).The colposcopy results showed 211 true-positive cases and 138 true-negative cases;the HPV E6/E7 mRNA test results showed 199 true-positive cases and 137 true-negative cases;the combined test results showed 239 true-positive cases and 174 true-negative cases.The sensitivity(95.22％),specificity(75.98％),accuracy(86.04％),positive predic-tive value(81.29％),and negative predictive value(93.55％)of the combined test were signifi-cantly higher than those of each individual test(P＜0.001).Moreover,the consistency between the combined test and pathological results(Kappa=0.718,P＜0.001)was also significantly high-er than that of each individual test.Conclusion Compared with HPV E6/E7 mRNA or colposcopy alone,the combined test has higher clinical application value in screening of cervical precancerous lesions and cervical cancer,shows stronger consistency with pathological results,and is of great sig-nificance for the early differential diagnosis of cervical precancerous lesions and cervical cancer.
