Relationships of serum levels of vascular endothelial growth factor,transforming growth factor-β,interleukin-1,and interleukin-6 with clinicopathological features in patients with endometrial cancer
- VernacularTitle:子宫内膜癌患者血清血管内皮生长因子、转化生长因子-β、白细胞介素-1、白细胞介素-6水平与临床病理特征的关系
- Author:
Yaqin YANG
1
;
Jiahui LI
;
Liping ZHAO
Author Information
- Keywords: endometrial cancer; cancer-associated fibroblasts; vascular endothelial growth factor; transforming growth factor-β1; interleukin-1; interleukin-6; clinicopathological features; tumor microenvironment
- From: Journal of Clinical Medicine in Practice 2025;29(15):12-16
- CountryChina
- Language:Chinese
- Abstract: Objective To analyze the changes in serum levels of cancer-associated fibroblast-re-lated factors[vascular endothelial growth factor(VEGF),transforming growth factor-β1(TGF-β1)]and inflammatory mediators[interleukin-1(IL-1),interleukin-6(IL-6)]in patients with endometrial cancer(EC)and their relationship with clinicopathological features.Methods A total of 180 pa-tients with EC were selected as EC group,and 100 patients with benign endometrial lesions who visi-ted the hospital during the same period were selected as control group.The serum levels of VEGF,TGF-β1,IL-1 and IL-6 were compared between the two groups,as well as among EC patients with different clinicopathological features.Spearman correlation analysis was used to examine the relation-ship between the above-mentioned serum indicators and clinicopathological features in EC patients.Results The serum levels of VEGF,TGF-β1,IL-1 and IL-6 in the EC group were higher than those in the control group,with statistically significant differences(P＜0.05).The serum levels of VEGF,TGF-β1,IL-1 and IL-6 in EC patients with a myometrial invasion depth ≥ 1/2 and lymph node metas-tasis were higher than those in EC patients with a myometrial invasion depth＜1/2 and no lymph node metastasis(P＜0.05).Spearman correlation coefficient analysis showed that the serum levels of VEGF,TGF-β1,IL-1 and IL-6 in EC patients were positively correlated with myometrial invasion depth and lymph node metastasis status,respectively(P＜0.05).Conclusion The serum levels of VEGF,TGF-β1,IL-1 and IL-6 are significantly elevated in EC patients.These indicators are sig-nificantly correlated with clinicopathological features and have potential value in the early diagnosis,prognosis assessment,and targeted therapy of EC.
