Value of multimodal ultrasound combined with immune-inflammatory indicators in predicting axillary lymph node metastasis in patients with breast cancer
- VernacularTitle:多模态超声联合免疫炎症指标预测乳腺癌腋窝淋巴结转移的价值
- Author:
Junhui LI
1
;
Shu GE
;
Jue WANG
;
Qing ZHANG
;
Chunlin YANG
Author Information
- Keywords: multimodal ultrasound; inflammatory indicators; breast cancer; lymph node me-tastasis; predictive efficacy; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; aspect ratio
- From: Journal of Clinical Medicine in Practice 2025;29(15):1-5
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the value of multimodal ultrasound combined with immune-inflammatory indicators in predicting axillary lymph node(ALN)metastasis in patients with breast cancer.Methods The clinical data of 106 breast cancer patients treated in the Ultrasound Depart-ment of Nantong Cancer Hospital from January 2023 to June 2024 were analyzed,and the patients were divided into ALN metastasis group and non-metastasis group based on postoperative pathological re-sults.Univariate and multivariate Logistic regression models were used to analyze the immune-inflam-matory indicators and ultrasound parameters in both groups.The receiver operating characteristic(ROC)curve was plotted to evaluate the predictive value of each indicator.Results Univariate anal-ysis showed significant differences between the ALN metastasis group and the non-metastasis group in terms of the neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),aspect ratio,maximum tumor diameter,and Adler blood flow grade(P＜0.05).NLR,PLR,maximum tumor di-ameter,and Adler blood flow grade were independent influencing factors for predicting ALN metastasis in breast cancer(P＜0.05).The area under the curve(AUC)for predicting ALN metastasis using multimodal ultrasound combined with immune-inflammatory indicators was 0.877,with a diagnostic sensitivity of 84.7％and a specificity of 76.6％.The predictive efficacy of the combined multi-indicators was significantly higher than that of individual indicators(P＜0.05).Conclusion Multimodal ultrasound combined with immune-inflammatory indicators is associated with ALN metastasis in breast cancer patients and can provide a reference basis for clinical diagnosis,subsequent treatment,and prognosis evaluation.
