Research progress on molecular mechanisms of lipid metabolism disorders mediating pulmonary vascular remodeling in pulmonary arterial hypertension
- VernacularTitle:脂代谢紊乱介导肺动脉高压血管重塑的分子机制研究进展
- Author:
Qi SUN
1
;
Yanming HE
;
Jinjing YUAN
;
Mengwen SHEN
;
Chunlei DING
;
Xinyi ZHANG
;
Lei ZHAO
Author Information
- Keywords: pulmonary vascular remodeling; pulmonary arterial hypertension; targeted vasodi-lator drugs; lipid metabolism disorders; endothelial-mesenchymal transition; fatty acid β-oxidation; bone morphogenetic protein receptor 2; pathological mechanism
- From: Journal of Clinical Medicine in Practice 2025;29(14):142-148
- CountryChina
- Language:Chinese
- Abstract: Pulmonary vascular remodeling is the core pathological feature in the onset and pro-gression of pulmonary arterial hypertension(PAH).Currently,there is no well-defined therapeutic strategy that can effectively delay or reverse this process.Despite the widespread clinical application of targeted vasodilator drugs,patients still face a high risk of mortality and adverse cardiovascular e-vents,suggesting an urgent need to explore new pathological mechanisms and therapeutic targets.In recent years,the relationship between dyslipidemia and PAH has garnered increasing attention.This article aimed to review the role of lipid metabolism disorders in pulmonary vascular remodeling in pul-monary arterial hypertension and its underlying mechanism,with the hope of providing new interven-tion targets for the treatment of PAH,thereby improving patient survival rates and quality of life.
