Relationship between dried fruit intake and risk of colorectal cancer:a two-sample Mendelian randomization study
- VernacularTitle:干果摄入与结直肠癌风险的关系:一项两样本孟德尔随机化研究
- Author:
Zhichao JIN
1
;
Hong DAI
;
Ran YANG
Author Information
- Keywords: dried fruit intake; colorectal cancer; Mendelian randomization; genome-wide as-sociation analysis; causal relationship; disease risk; inverse variance weighted method; weighted me-dian method
- From: Journal of Clinical Medicine in Practice 2025;29(13):39-43,49
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the causal relationship between dried fruit intake and color-ectal cancer(CRC)by using a two-sample Mendelian randomization(MR)approach.Methods Two-sample MR analysis was conducted utilizing summary data from genome-wide association studies on dried fruit intake and colorectal cancer.Separate analyses were performed using data for colon cancer and rectal cancer for validation.Genetic variants significantly and independently associated with dried fruit intake were selected as instrumental variables.The inverse variance weighted method,MR-Egger regression,weighted median method,simple mode method,and weighted mode method were employed as the primary analytical approaches.Heterogeneity tests,pleiotropy analysis,and sensitivity analysis were conducted to evaluate the reliability of the study.Results A total of 21 single nucleotide poly-morphisms(SNPs)associated with dried fruit intake were included as instrumental variables.The in-verse variance weighted analysis revealed that increased dried fruit intake was associated with a reduced risk of colorectal cancer(OR=0.55,95％CI,0.32 to 0.96,P=3.53 × 10-2),with consistent results observed for both colon cancer and rectal cancer.The findings of this study were not influenced by plei-otropy or heterogeneity,and the reliability of the results was validated by sensitivity analysis.Conclu-sion Increasing dried fruit intake has potential preventive value against colorectal cancer.
