Mitochondrial dysfunction in microglia:emerging mechanisms and therapeutic implications in Parkinson's disease
- VernacularTitle:小胶质细胞线粒体功能障碍:帕金森病的新机制和治疗意义
- Author:
Ruoxun WANG
1
;
Ziqi LIU
;
Xinrui LAN
;
Li QIAN
Author Information
- Keywords: microglia; Parkinson's disease; energy metabolism; mitochondrial dynamics; mi-tophagy; mitochondrial transfer; alpha-synuclein; reactive oxygen species
- From: Journal of Clinical Medicine in Practice 2025;29(12):135-141
- CountryChina
- Language:Chinese
- Abstract: Parkinson's disease(PD)is the second most prevalent neurodegenerative disorder globally,and its pathogenesis remains incompletely understood.Mitochondrial dysfunction in micro-glia serves as a crucial factor in the onset and progression of PD,with studies on mitochondrial disor-ders playing a vital role in elucidating the pathogenesis of PD.A profound understanding of the rela-tionship between mitochondrial dysfunction and microglia activation in PD is of great significance for unraveling the pathogenesis,diagnosis,and treatment of PD.This review summarized the research progress on the roles of mitochondrial energy metabolism disorders,dynamic imbalance,autophagy defects,and mitochondrial transfer in the activation of microglia in PD.
