Analysis of change trajectories and influencing factors of medication adherence in middle-aged and young patients with hypertension
- VernacularTitle:中青年高血压患者服药依从性的变化轨迹及影响因素分析
- Author:
Yun CHEN
1
;
Yang YANG
;
Lihua WANG
;
Haiyan GU
;
Dandan LI
Author Information
- Keywords: latent growth mixture modeling; the middle-aged and young; hypertension; medication adherence; medication beliefs; self-management behaviors; family care degree; multiva-riate Logistic regression analysis
- From: Journal of Clinical Medicine in Practice 2025;29(11):79-84
- CountryChina
- Language:Chinese
- Abstract: Objective To identify latent classes of medication adherence change trajectories in middle-aged and young patients with hypertension based on the Latent Growth Mixture Modeling(LGMM)and analyze its influencing factors.Methods A convenience sampling method was used to select 258 middle-aged and young patients with hypertension as study subjects.A cross-sectional sur-vey was conducted on their general information,medication beliefs,self-management behaviors,and Family Care Index.Medication adherence was assessed one day before discharge(T0),one month after discharge(T1),three months after discharge(T2),and six months after discharge(T3).LGMM was used to identify latent classes of change trajectories,and univariate analysis and multivari-ate Logistic regression analysis were conducted to explore the influencing factors.Results After ex-cluding 30 invalid data,228 patients were ultimately included in this study.LGMM fitting results showed that medication adherence change trajectories comprised three latent classes:low adherence-fluctuating group(31.58％),medium adherence-continuously increasing group(32.46％),and high adherence-gradually declining group(35.96％).Multivariate Logistic regression analysis results indi-cated that age,medication types,medication belief scores,self-management behavior scores,and Fam-ily Care Index scores were all independent influencing factors for latent classes of medication adherence change trajectories in middle-aged and young patients with hypertension(P＜0.05).Conclusion There is significant population heterogeneity in medication adherence among middle-aged and young pa-tients with hypertension,with varying change trajectories observed.Healthcare professionals should identify target populations early and formulate targeted intervention programs based on the influen-cing factors of different latent classes to effectively improve patients' medication adherence.
