Research progress of non-coding RNA in recurrent spontaneous abortion
- VernacularTitle:非编码RNA在复发性自然流产中的研究进展
- Author:
Guoyun ZHAO
1
;
Zhinan MA
;
Tianfeng HUANG
;
Changning LIANG
;
Tao HUANG
Author Information
- Keywords: non-coding RNA; recurrent spontaneous abortion; immune microenvironment; trophoblast cells; competitive endogenous RNA; vesicular transport; circular RNA; microRNA
- From: Journal of Clinical Medicine in Practice 2025;29(10):134-139
- CountryChina
- Language:Chinese
- Abstract: Recurrent spontaneous abortion(RSA)has complex etiologies,including embryonic chromosomal abnormalities,maternal immune factors,prethrombotic states,and uterine anatomical a-nomalies.Currently,the pathogenesis of RSA remains incompletely elucidated,with placental tropho-blast dysfunction considered a key factor contributing to pregnancy failure.Recent studies have dem-onstrated that non-coding RNA(ncRNA)are stably expressed at the maternal-fetal interface and reg-ulate the proliferation,apoptosis,invasion,and metastasis of trophoblast immune cells.The ncRNA can directly modulate target gene expression or influence the occurrence and progression of RSA through competitive endogenous RNA(ceRNA)regulatory networks,providing novel targets for re-searchers exploring the pathogenesis of RSA.Additionally,ncRNA mediate intercellular interactions via vesicular transport,offering new insights into their regulatory mechanisms.Due to their tissue spe-cificity and expression stability,ncRNA are promising as novel biomarkers for RSA and other preg-nancy-related disorders.This review summarized the regulatory roles of ncRNA in the immune mecha-nisms underlying the occurrence and development of RSA based on multiple domestic and internation-al studies.
