Research Progress of plant exosome-like nanovesicles in treatment of skeletal disorders
- VernacularTitle:植物外泌体样纳米囊泡在骨骼疾病治疗中的研究进展
- Author:
Nan WU
1
;
Qiangqiang GUO
;
Hua GUO
Author Information
- Keywords: exosome; extracellular vesicles; plant; osteoporosis; osteoarthritis; targeted de-livery; biocompatibility; extraction
- From: Journal of Clinical Medicine in Practice 2025;29(9):130-135,142
- CountryChina
- Language:Chinese
- Abstract: Plant exosome-like nanovesicles(PELNs)are extracellular nanoparticles(30 to 300 nm in diameter)secreted by plant cells,characterized by a unique lipid-protein-nucleic acid compo-sition and functional attributes.These vesicles play pivotal roles in plant metabolism,immune de-fense,and the regulation of cellular physiological activities across species.This review systematically summarized recent research advances in PELNs,encompassing their biogenesis pathways,composi-tional analysis,extraction/isolation protocols,storage stability,identification methodologies,and ap-plications in skeletal system disorders.Critical challenges and future research directions in this field also discussed,providing valuable references for subsequent investigations.
