Research progress on regulation of autophagy in osteoarthritis chondrocytes by microRNAs
10.7619/jcmp.20245609
- VernacularTitle:微小RNA调节骨关节炎软骨细胞自噬的研究进展
- Author:
Fuchao DING
1
;
Puwei YUAN
;
Panxin MA
;
Hu YANG
Author Information
1. 陕西中医药大学,陕西咸阳,712000
- Keywords:
microRNA;
autophagy;
chondrocyte;
osteoarthritis;
degenerative lesion;
cell ap-optosis;
therapeutic target;
pathogenesis
- From:
Journal of Clinical Medicine in Practice
2025;29(9):124-129
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis(OA)is a degenerative joint disease primarily characterized by articular cartilage degeneration.Autophagy is a crucial intracellular homeostatic system that plays a vital role in maintaining normal cartilage function.By regulating cell apoptosis and repairing damaged chondro-cytes,autophagy protects cartilage,and dysfunction in chondrocyte autophagy is an important patho-genic mechanism underlying cartilage degeneration in OA.MicroRNAs(miRNA)can regulate gene expression and play a key role in chondrocyte development and functional maintenance.MiRNA in-volved in the regulation of autophagy are aberrantly expressed in OA,suggesting that miRNAs may serve as potential targets and biomarkers for early prediction,diagnosis,and effective treatment of OA.This review discussed the role of autophagy in OA and the regulatory role of miRNA in OA de-velopment,with a focus on the role of miRNA-mediated regulation of chondrocyte autophagy in OA pathogenesis and its potential therapeutic value.
