Correlations of anemia with disease activity and treatment outcomes in patients with psoriatic arthritis:a retrospective cohort study
- VernacularTitle:银屑病关节炎患者贫血与疾病活动度及治疗结局的相关性——一项回顾性队列研究
- Author:
Qian ZHANG
1
;
Yunjuan WU
;
Yao KE
;
Rui LIU
Author Information
- Keywords: psoriatic arthritis; anemia; disease activity; the American College of Rheuma-tology 20％ improvement criteria; composite psoriatic disease activity index; disease-modifying an-tirheumatic drugs; skin lesions; peripheral arthritis
- From: Journal of Clinical Medicine in Practice 2025;29(9):80-85
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the incidence of anaemia in patients with psoriatic arthritis(PsA)and explore the relationship between serum hemoglobin(Hb)levels and disease activity and treatment outcomes.Methods Clinical data of PsA patients who visited the Department of Rheuma-tology and Immunology of the First Affiliated Hospital of Nanjing Medical University from March 2019 to May 2024 were collected.Anemia was determined based on Hb values(female＜110 g/L,male＜120 g/L),and clinical characteristics were compared between anemic and non-anaemic patients.Multivariate Logistic regression analysis was used to identify factors associated with treatment response.Results Among anemic patients,the proportion of males was higher than that of females,and the difference was statistically significant(P=0.03).The incidence of skin lesions(P=0.002),pe-ripheral arthritis(P＜0.001),spondylitis(P＜0.001),and enthesitis(P＜0.001)was higher in the anemic group than in the non-anemic group,with statistically significant differences.Patients with anemia had higher composite psoriatic disease activity index(CPDAI)(P＜0.008)and acute-phase reactant levels(P＜0.001),and the differences were statistically significant.Multivariate logistic re-gression analysis showed that patients with concomitant anemia were less likely to achieve the Ameri-can College of Rheumatology 20％improvement criteria(ACR20)than those without concomitant anemia(OR=0.36,P=0.02).Conclusion Anaemia is a common complication of PsA,associated with high disease activity and is a predictor of poor treatment response.
