Effect of modified Taohong Siwu Decoction combined with nadroparin on platelet activation markers and hemorheology in patients undergoing hip replacement
- VernacularTitle:桃红四物汤加减联合那屈肝素对髋关节置换术患者血小板活化指标及血液流变学的影响
- Author:
Lizhong YANG
1
;
Ke HU
Author Information
- Keywords: hip replacement; deep venous thrombosis of the lower extremities; Taohong Si-wu Decoction; thrombin molecules; platelet activation markers; hemorheology; nadroparin; positive rate of affected limb swelling
- From: Journal of Clinical Medicine in Practice 2025;29(9):25-28,34
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the effect of modified Taohong Siwu Decoction combined with nadroparin in preventing deep venous thrombosis(DVT)of the lower extremities after hip re-placement.Methods A total of 85 patients undergoing hip replacement were randomly divided into experimental group(n=43)and conventional group(n=42).The conventional group received nadr-oparin postoperatively,while the experimental group received modified Taohong Siwu Decoction com-bined with nadroparin.The incidence of DVT,positive rate of limb swelling,coagulation factors[D-dimer(D-D),fibrinogen degradation products(FDP),plasmin-α2 plasmin inhibitor complex(PIC),thrombin-antithrombin Ⅲ complex(TAT)],platelet activation markers[glycoprotein Ⅱb/Ⅲa(GP Ⅱb/Ⅲa),P-selectin(CD62P),granule membrane protein 140(GMP-140),platelet glycoprotein fibrinogen receptor-1(PAC-1)],hemorheological indicators(plasma viscosity,low-shear whole blood viscosity,medium-shear whole blood viscosity,high-shear whole blood viscosity),and the occurrence of bleeding events were compared between the two groups before and after surgery.Results The inci-dence of DVT and positive rate of affected limb swelling were lower in the experimental group than those in the conventional group(P＜0.05).Fourteen days after treatment,the plasma levels of D-D,FDP,TAT,PIC,GP Ⅱb/Ⅲa,CD62P,GMP-140,PAC-1,as well as high-shear whole blood viscosity,medium-shear whole blood viscosity,low-shear whole blood viscosity,and plasma viscosity were all lower in the experimental group than those in the conventional group(P＜0.05).No bleeding events occurred in either group during treatment.Conclusion Modified Taohong Siwu Decoction combined with na-droparin can improve the thrombin and platelet status in patients after hip replacement,restore blood microcirculation,reduce the risk of DVT in the lower extremities,and alleviate swelling.
