Aduances of abnormal lipid metabolism in neurodegenerative diseases
- VernacularTitle:神经退行性疾病异常脂质代谢的研究进展
- Author:
Jing LU
1
;
Mengzhuo ZHU
;
Xichen ZHU
;
Tao MA
Author Information
- Keywords: lipid; brain development; neurodegenerative disease; Alzheimer's disease; Par-kinson's disease; multiple system atrophy; abnormal lipid metabolism; intervention target
- From: Journal of Clinical Medicine in Practice 2025;29(8):143-148
- CountryChina
- Language:Chinese
- Abstract: Lipids play biological roles in brain growth and development,including energy stor-age,cellular signal transduction,hormone synthesis,and homeostasis maintenance.Lipid dysregula-tion is closely associated with the occurrence and progression of neurodegenerative diseases,making brain lipids important biomarkers for assessing early diagnosis and prognosis of neurological disorders.This article reviewed abnormal lipid metabolism in Alzheimer's disease,Parkinson's disease,and multiple system atrophy,focusing on the possible mechanisms of interaction between β-amyloid(A β),α-synuclein(α-syn),phosphorylated Tau protein,and associated lipids and their metabo-lites.It also summarized key targets for improving neurodegeneration through intervention in brain lip-id metabolism pathways.
